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Identification and ecotoxicity assessment of intermediates generated during the degradation of clofibric acid by advanced oxidation processes

Wenzhen LI, Yu DING, Qian SUI, Shuguang LU, Zhaofu QIU, Kuangfei LIN

Frontiers of Environmental Science & Engineering 2012, Volume 6, Issue 4,   Pages 445-454 doi: 10.1007/s11783-012-0419-6

Abstract: The acute toxicity was evaluated by means of T spp. bioassay.

Keywords： clofibric acid     advanced oxidation processes     intermediates     toxicity     <italic>Photobacterium phosphoreumitalic> T3 spp    

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Ductile extension of 3-D external circumferential cracks in pipe structures

Wuchao YANG, Xudong QIAN

Frontiers of Structural and Civil Engineering 2011, Volume 5, Issue 3,   Pages 294-303 doi: 10.1007/s11709-011-0115-9

Abstract: This study investigates the ductile fracture resistance of 3-D external circumferential cracks in theThe fracture resistance along the 3-D semi-elliptical crack front is computed from the calibrated cellequivalent 2-D axi-symmetric model provides conservative estimations of the fracture resistance for 3-

Keywords： ductile fracture     computational cell method     G-T model     <italic>J-Ritalic> curve    

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Spatial and seasonal variations in bacterial communities of the Yellow Sea by T-RFLP analysis

Hongyuan WANG, Xiaolu JIANG, Ya HE, Huashi GUAN

Frontiers of Environmental Science & Engineering 2009, Volume 3, Issue 2,   Pages 194-199 doi: 10.1007/s11783-009-0018-3

Abstract: This was accomplished by using terminal restriction fragment length polymorphism (T-RFLP) analysis ofThe MDA analysis results of T-RFLP profiles coming from I and I both exhibited a significant seasonal

Keywords： terminal restriction fragment length polymorphism (T-RFLP)     bacterial community structure     marine microbialdiversity     <italic>Hhaitalic>I     <italic>Mspitalic>I    

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Separation of epigallocatechin-3-gallate from crude tea polyphenols by using Cellulose diacetate graft

Hong ZHU, Peiyong QIN

Frontiers of Chemical Science and Engineering 2011, Volume 5, Issue 3,   Pages 330-338 doi: 10.1007/s11705-010-1104-6

Abstract: asymmetric membrane prepared by a phase inversion technique for the separation of (-)-epigallocatechin-3-

Keywords： (-)-epigallocatechin-3-gallate (EGCG)     tea polyphenols     CDA-<italic>βitalic>-CD    

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CRISPR-Cas9 mediated LAG-3 disruption in CAR-T cells

Yongping Zhang, Xingying Zhang, Chen Cheng, Wei Mu, Xiaojuan Liu, Na Li, Xiaofei Wei, Xiang Liu, Changqing Xia, Haoyi Wang

Frontiers of Medicine 2017, Volume 11, Issue 4,   Pages 554-562 doi: 10.1007/s11684-017-0543-6

Abstract:

T cells engineered with chimeric antigen receptor (CAR) have been successfully applied to treat advancedOne negative regulator of T cell activity is lymphocyte activation gene-3 (LAG-3).We successfully generated LAG-3 knockout T and CAR-T cells with high efficiency using LAG-3 knockout CAR-T cells displayed robust antigen-specific antitumor activity incell culture and in murine xenograft model, which is comparable to standard CAR-T cells.

Keywords： CAR-T     CRISPR-Cas9     LAG-3    

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spp., foodborne pathogens threatening neonates and infants

Qiming CHEN, Yang ZHU, Zhen QIN, Yongjun QIU, Liming ZHAO

Frontiers of Agricultural Science and Engineering 2018, Volume 5, Issue 3,   Pages 330-339 doi: 10.15302/J-FASE-2018208

Abstract:

Cronobacter spp.Cronobacter spp. can resist dry environments and survive for a long period in food with low waterTherefore, Cronobacter spp. have become serious pathogens of neonates and infants, as well asreview, we present the taxonomy, pathogenesis, resistance, detection and control of Cronobacter spp

Keywords： Cronobacter spp.    

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Optimization of cellulase production using

Saravanan P, Muthuvelayudham R, Rajesh Kannan R, Viruthagiri T

Frontiers of Chemical Science and Engineering 2012, Volume 6, Issue 4,   Pages 443-452 doi: 10.1007/s11705-012-1225-1

Abstract: the optimum experimental conditions: pH (5.5), temperature (37.5°C), initial substrate concentration (3%

Keywords： cellulase     pineapple waste     <italic>Trichoderma reeseiitalic>     Box-Behnken design     genetic algorithm    

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Influence and related mechanism of Retn gene expression on glucose uptake in 3T3-L1 cells

LI Yahui, DONG Shiyuan, YU Chao, JIANG Yu, LI Huaixing, SUN Shuhan

Frontiers of Medicine 2007, Volume 1, Issue 3,   Pages 269-273 doi: 10.1007/s11684-007-0051-1

Abstract: investigate the influence and the related mechanism of the gene on glucose uptake and insulin resistance in 3T3Radioimmunoassay was used to determine glucose uptake in 3T3-L1 cells with different gene expressionreal-time RT-PCR analysis were used to determine the mRNA levels of several glucose transport proteins in 3T3The glucose uptake decreased with the increase in gene expression in 3T3-L1 cells, which was independent, GSK-3 and p38MAPK, increased with overexpression in 3T3-L1 cells.

Keywords： 3T3-L1     influence     resistance     receptor substrate-1     transport    

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Novel mutation c.1210-3C>G in with a poly-T tract of 5T affects mRNA splicing in a Chinese patient

Frontiers of Medicine 2022, Volume 16, Issue 1,   Pages 150-155 doi: 10.1007/s11684-021-0846-5

Abstract: The patient is a compound heterozygote of c.2909G>A, p.Gly970Asp in exon 18 and c.1210-3C>G in cis with a poly-T of 5T (T5) sequence, 3 bp upstream in intron 9.plasmid containing c.1210-3C together with T7 sequence produced a normal transcript and partial exon10-skipping-transcript, whereas mutant plasmid containing c.1210-3G in cis with T5 sequence causedOverall, c.1210-3C>G, the newly identified pathogenic mutation in our patient, in combination with T5

Keywords： cystic fibrosis     CFTR     splicing mutation     minigene    

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A CASE FOR ASSESSING ALLOCASUARINA AND CASUARINA SPP.

Frontiers of Agricultural Science and Engineering 2021, Volume 8, Issue 4,   Pages 568-582 doi: 10.15302/J-FASE -2019270

Abstract:

Agroecosystems in water-limited contexts— Mediterranean, semi-arid and arid climatic zones—are too frequently degraded systems that will not provide the needed ecosystem services to ensure a future of sustainable agricultural production. The processes that have created this situation continue and are being accelerated by anthropogenic climate change. Increasing arboreal vegetation in these areas through agroforestry is an important strategy to conserve and improve their agroecosystems. Actinorhizal trees and shrubs in the Casurinaceae have a unique set of adaptations for heat and water stress, and/or infertile to hostile soils. Central Anatolia, Turkey is particularly at risk of increasing aridity and further degradation. Therefore, species of Allocasuarina and Casuarina have been evaluated for their potential use in agroecosystem improvement in semi-arid areas with a focus on Central Anatolia. Based on a semiquantitative environmental tolerance index and reported plant stature, eight species were identified as being of high (A. verticillata and C. pauper) to moderate (A. acutivalvis, A. decaisneana, A. dielsiana, A. huegeliana, C. cristata and C. obesa) priority for assessment, with none of these species having been adequately evaluated for agroforestry deployment in semi-arid agroecosystems in any context.

 

Keywords： actinorrhizal trees / agroforestry / climate change / ecosystem restoration    

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Changes of phenotype and function of human CD4 CD25 T cells induced by transfection of Foxp3

WU Kui, BI Yutian, WANG Yaoli, WANG Changzheng

Frontiers of Medicine 2008, Volume 2, Issue 4,   Pages 366-369 doi: 10.1007/s11684-008-0070-6

Abstract: of naive CD4 T cells.The pMSCV-Foxp3 retroviral vector encoding Foxp3 gene was transduced into the PT67 packaging cell lineFoxp3-gene transfected CD4 T cells could express Foxp3 and transfection of Foxp3 gene up-regulated theCD4CD25 T cells acquired a regulatory phenotype and function after it was transduced with the Foxp3 geneThis suggested a key role of Foxp3 in the generation of CD4CD25 regulatory T cells.
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The <italic>rpoSitalic> deficiency suppresses acetate accumulation in glucose-enriched culture of <italic>Escherichia coliitalic> under an aerobic condition

Prayoga SURYADARMA, Yoshihiro OJIMA, Yuto FUKUDA, Naohiro AKAMATSU, Masahito TAYA

Frontiers of Chemical Science and Engineering 2012, Volume 6, Issue 2,   Pages 152-157 doi: 10.1007/s11705-012-1287-0

Abstract: The role of on the central carbon metabolism was investigated through analyzing the deficiency of this regulon gene under aerobic and glucose-enriched culture conditions. The experimental results showed that while the wild type cells exhibited an overflow metabolism effect, the -deleting mutation alleviated this effect with the significant suppression of acetate accumulation under a high glucose condition. This gene deletion also induced the twofold upregulation of and one-tenth downregulation of , respectively. The overflow metabolism effect was confirmed to be recovered by re-introducing gene into the mutant. These results demonstrated changed the central carbon metabolism toward acetate overflow through dehydrogenation of pyruvate and reduction of TCA cycle activity.

Keywords： <italic>Escherichia coliitalic>     <italic>rpoSitalic>     aerobic and glucose-enriched culture     overflow    

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Synthesis of depsipeptides from

Hongfei CAO, Yakai FENG, Heyun WANG, Li ZHANG, Musammir KHAN, Jintang GUO

Frontiers of Chemical Science and Engineering 2011, Volume 5, Issue 4,   Pages 409-415 doi: 10.1007/s11705-011-1141-9

Abstract: By using the corresponding -amino acid sodium as initiator, -caprolactone-depsipeptides CL-Ala and CL-Leu were prepared by the reactions of -caprolactone (CL) with -alanine and -leucine, respectively, and -dioxanone-depsipeptide (PDO-Leu) was prepared by the reaction of -dioxanone (PDO) with -leucine. Two poly( -caprolactone) oligomers (PCL-Ala and PCL-Leu) of different molecular weights with depsipeptide unit were synthesized by controlling the feed ratio of -amino acid sodium and CL. The presence of the depsipeptide structure in these obtained products was confirmed by H NMR spectra and the molecular weight of the poly( -caprolactone) oligomers was measured by gel permeation chromatography (GPC). These products contain a hydroxyl group and a carboxyl group in one molecule, which means they could act as bifunctional monomers for further polymerization to prepare high molecular weight polymers. By this way, the depsipeptide unit could be introduced into the polymers and the biodegradation rates of the novel polymers could be well controlled in vivo by the tailored molecular structures.

Keywords： <italic>?italic>-caprolactone     <italic>pitalic>-dioxanone     <italic>Litalic>-alanine     <italic>Litalic>-leucine    

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randomized trials of maintenance bacillus Calmette-Guerin instillation efficacy against recurrence of T1G3

PAN Jiangang, ZHOU Xing, CHEN Zhiguang, HAN Ruifa

Frontiers of Medicine 2008, Volume 2, Issue 3,   Pages 259-263 doi: 10.1007/s11684-008-0049-3

Abstract: bacillus Calmette-Guerin (BCG) could reduce recurrence after transurethral resection of tumor 1 grade 3(T1G3) superficial bladder cancer.resection plus another treatment on the treatment results in patients with superficial bladder cancer of T1G3resection of bladder tumor (TURBT) is an effective conservative treatment for preventing recurrence of T1G3
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Assessment of toxicity of two nitroaromatic compounds in the freshwater fish

Hongyan SHEN, Jixi GAO, Jinsheng WANG

Frontiers of Environmental Science & Engineering 2012, Volume 6, Issue 4,   Pages 518-523 doi: 10.1007/s11783-012-0427-6

Abstract: This study was conducted to evaluate the toxicological response of -nitrotoluene and -nitroaniline to the key fish species, . A freshwater fish bioassay based on the 96 h was used to estimate the single and joint toxicity of the two chemicals. The toxicity of -nitrotoluene was greater than that of -nitroaniline based on 96 h values of 40.74 mg·L and 48.99 mg·L , respectively. Both compounds had moderate toxicity toward , and this toxicity increased with the exposure duration and concentration. Binary mixtures of the compounds were more toxic than the individual compounds at 96 h, and they acted upon partial addition. When the exposure time was longer, the toxicity increased for mixtures of compounds with the same concentration or toxicity. The results of this study suggest that exposure to a combination of these chemicals would result in a higher environmental risk in aquatic systems than exposure to either compound alone. Further research is needed to investigate the combined effects and sublethal toxicity of -nitrotoluene and -nitroaniline, since they are both still used in China.

Keywords： joint toxicity     <italic>Cyprinus carpioitalic>     <italic>LCitalic>50     <italic>pitalic>-nitrotoluene     <italic>pitalic>-nitroaniline     toxic unit    

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Title Author Date Type Operation

Identification and ecotoxicity assessment of intermediates generated during the degradation of clofibric acid by advanced oxidation processes

Wenzhen LI, Yu DING, Qian SUI, Shuguang LU, Zhaofu QIU, Kuangfei LIN

Journal Article

Ductile extension of 3-D external circumferential cracks in pipe structures

Wuchao YANG, Xudong QIAN

Journal Article

Spatial and seasonal variations in bacterial communities of the Yellow Sea by T-RFLP analysis

Hongyuan WANG, Xiaolu JIANG, Ya HE, Huashi GUAN

Journal Article

Separation of epigallocatechin-3-gallate from crude tea polyphenols by using Cellulose diacetate graft

Hong ZHU, Peiyong QIN

Journal Article

CRISPR-Cas9 mediated LAG-3 disruption in CAR-T cells

Yongping Zhang, Xingying Zhang, Chen Cheng, Wei Mu, Xiaojuan Liu, Na Li, Xiaofei Wei, Xiang Liu, Changqing Xia, Haoyi Wang

Journal Article

spp., foodborne pathogens threatening neonates and infants

Qiming CHEN, Yang ZHU, Zhen QIN, Yongjun QIU, Liming ZHAO

Journal Article

Optimization of cellulase production using

Saravanan P, Muthuvelayudham R, Rajesh Kannan R, Viruthagiri T

Journal Article

Influence and related mechanism of Retn gene expression on glucose uptake in 3T3-L1 cells

LI Yahui, DONG Shiyuan, YU Chao, JIANG Yu, LI Huaixing, SUN Shuhan

Journal Article

Novel mutation c.1210-3C>G in with a poly-T tract of 5T affects mRNA splicing in a Chinese patient

Journal Article

A CASE FOR ASSESSING ALLOCASUARINA AND CASUARINA SPP.

Journal Article

Changes of phenotype and function of human CD4 CD25 T cells induced by transfection of Foxp3

WU Kui, BI Yutian, WANG Yaoli, WANG Changzheng

Journal Article

The <italic>rpoSitalic> deficiency suppresses acetate accumulation in glucose-enriched culture of <italic>Escherichia coliitalic> under an aerobic condition

Prayoga SURYADARMA, Yoshihiro OJIMA, Yuto FUKUDA, Naohiro AKAMATSU, Masahito TAYA

Journal Article

Synthesis of depsipeptides from

Hongfei CAO, Yakai FENG, Heyun WANG, Li ZHANG, Musammir KHAN, Jintang GUO

Journal Article

randomized trials of maintenance bacillus Calmette-Guerin instillation efficacy against recurrence of T1G3

PAN Jiangang, ZHOU Xing, CHEN Zhiguang, HAN Ruifa

Journal Article

Assessment of toxicity of two nitroaromatic compounds in the freshwater fish

Hongyan SHEN, Jixi GAO, Jinsheng WANG

Journal Article